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Antidepressants may dampen the effects of some common opioids, resulting in less effective pain management according to research findings published Wednesday. The researchers suggest physicians should consider alternative pain management strategies for patients on antidepressants.

Opioids come in two broad varieties: those that act directly and others that have to be chemically processed by the body before they can begin to relieve pain. Direct-acting opioids, like morphine or oxycodone, can get right to work.

Trump administration health officials are spelling out their ambitious plan to stop the spread of HIV in the U.S. within the next 10 years.

The plan would target 48 counties where the rate of HIV spread is the highest, along with Washington, D.C., and San Juan, Puerto Rico. Seven states with high rates of HIV in rural areas would also be targeted, including Oklahoma, Missouri, Kentucky, Arkansas, Alabama, South Carolina and Mississippi.

Health was a persistent theme, if not the centerpiece, of President Trump's State of the Union address at the Capitol on Tuesday night.

The president laid out a series of health-related goals, including some that even Democrats indicated could be areas of bipartisan negotiation or compromise. Trump vowed to take on prescription drug prices, pursue an end to the HIV epidemic in the U.S. by 2030 and boost funding for childhood cancers.

New Mexico Gov. Michelle Lujan Grisham has ordered the majority of National Guard troops deployed at her state's Southern border to withdraw, condemning what she called a "charade of border fear-mongering" by President Trump, who has warned of an immigration emergency in the region.

"I reject the federal contention that there exists an overwhelming national security crisis at the Southern border," Lujan Grisham said, adding that the area has "some of the safest communities in the country."

Updated at 12:50 p.m. ET

As a rule, presidents want to have it both ways in their annual State of the Union addresses.

They want to "reach out to all Americans" with uplifting appeals to unity and bipartisanship. But they can't resist pumping up the pep rally for their party and most loyal supporters.

If that applies to all presidents in all seasons, it surely applied Tuesday night to President Trump, who has found the halfway point of his term to be fraught with political travail.

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According to Greek mythology, the cunning King Sisyphus of Ephyra received the ultimate punishment at the end of his days: damnation and an eternity spent pushing a rock up a mountain

On a sun-baked intersection of Ponce de Leon Avenue, a street named for the Spanish colonizer whose false claim to fame was discovering the fountain of youth, sits one of the most conspicuous cultural attractions in Atlanta. Mister Car Wash may be the busiest destination of its kind in a Southern capital where car washes are outnumbered only slightly by churches and chicken wing stops. It also happens to be the location of a pivotal pit stop in the rapid rise of one of hip-hop's brightest new stars.

"If you have a crappy meal, it just feels like a crappy part of my day," says Jen Van Fleet, an educator in Davenport, Iowa.

It has been a tough year in her school district. There have been new hires and budget cuts and extra work that has kept everyone busier than usual. Just before Thanksgiving, she was commiserating with her friends about the year and her mediocre lunches when someone had a brilliant idea: start a lunch club.

President Trump delivered a wide-ranging State of the Union address Tuesday night that went an hour and 21 minutes. That's the third-longest ever.

So what should we make of Trump's third address to Congress, and in a year when Democrats are gearing up for a crowded primary to decide who will face Trump in 2020?

1. Trump did not acknowledge the new political reality in Washington

Kurt Vile exudes a casualness at the Tiny Desk in his style and body language that is so unlike most anxious artists who come to play behind my desk. Sure, he's done this Tiny Desk thing before, with Courtney Barnett.

The president begged for unity before unleashing a speech that focused squarely on his most controversial policy. A traditional show of support from the speaker of the House turned into a sarcastic instant meme.

Such is politics in 2019.

It seemed like a mistake: When President Trump touted women's gains in the job market during his State of the Union address Tuesday, it sent the contingent of Democratic women to their feet in enthusiastic applause.

Many of those women, after all, had new jobs as a result of a record-smashing midterm election that was widely seen as a rebuke of Trump. And their white attire, in observation of the 100th anniversary of Congress voting to grant women the right to vote, highlighted their celebration even more.

California Attorney General Xavier Becerra says he plans to sue the Trump administration the moment the president declares a national emergency to free up funds for a border wall.

Becerra was responding in Spanish to President Trump's State of the Union address to Congress. But he released his response before Trump even delivered the first words of his remarks, anticipating a speech in which the president doubled down on his demand for the construction of a wall at the U.S.-Mexico border.

Stacey Abrams, former Georgia gubernatorial candidate and potential Senate candidate, delivered the Democrats' response to President Trump's State of the Union address on Tuesday night.

President Trump delivered his State of the Union address Tuesday night, a speech that had been delayed during the government shutdown.

The annual remarks came as a bipartisan group of lawmakers continue to negotiate border security funding and Trump's wall proposal — the central issue that led to the longest shutdown in U.S. history.

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